Abstract

ABSTRACT Beta thalassemia syndrome are a group of hereditary blood disorders in which or absent beta globin chain synthesis, results in reduced Hemoglobin, decreased RBC production and anemia. Total 300 individuals were divided into 4 groups according to age and gender i.e ≤13 years females, >13 years females, ≤13 years and >13 years males. Height in centimeter, weight in kilogram was measured to calculate BMIKg/m2. Serum ferritin (ng/mL) and hemoglobin (gm/dl) alongwith hormonal assay of GH (ng/mL), T3 (ng/mL), T4 (µg/dL), TSH (μIU/mL), and kisspeptin (ng/ml) was done. BMI and hemoglobin were significantly reduced (P<0.001), while serum ferritin were significantly increased (P<0.001) in all four thalassemic groups on comparison with control. Kisspeptin levels were significantly reduced in ≤13 years female (P<0.001). While significantly high levels were observed in >13 years of male (P<0.01). T3 levels were significantly increased in both thalassemic groups of female (P<0.01). While T4 levels were significantly reduced in ≤13 years of male alongwith significantly reduced (P<0.05) TSH levels. In >13 years male significantly increased (P<0.01) TSH levels were obtained. Growth hormone levels were significantly reduced (P<0.001) in both male and female thalassemic groups of ≤13 years. While significantly raised (P<0.001) hormone levels were observed in male and female thalassemic groups of >13 years. In >13 thalassemic female T3 had a negative correlation (P<0.05) with BMI and hemoglobin, while a positive correlation (P<0.001) of T3 with hemoglobin was observed in thalassemic male of ≤13 years. In >13 years male T3 had a positive correlation (P<0.05) with kisspeptin. T4 in all four thalassemic groups had a significant positive correlation with hemoglobin (P<0.05). TSH in >13 years female had a significant positive correlation with BMI, ferritin and hemoglobin (P<0.001). Results revealed that hypothalamic pituitary axis had proper production, other factors miught be involved in delaying the growth spurt.