Abstract

Objective: To determine the co-rrelation between serum leptin levels and systolic and diastolic blood pressure in normalpregnant and pre eclampsia patients.Material and Methods: This study was conducted at Gynae OPD Hayatabad Medical Complex, Lady Reading Hospital,Peshawar and Department of Pathology, Peshawar Medical College from January 2013 to July 2013. This was a casecontrol study in which sample size was 80 subjects. These were divided into two groups, 40 cases and 40 controls.Inclusion criteria include all patients with mild and severe pre-eclampsia having gestational age more than 20 weeks.Exclusion criteria including pregnant females having heart disease or kidney disease and gestational age less than20 weeks.Results: Cases were divided into mild and severe pre-eclampsia. The mean age of cases was 27 years and controlswere 24.9 years. Mean period of gestation of both cases and controls was 35.3 weeks. Mean B.P of cases was 153/100mmHg, while that of controls was 111/75mmHg. The mean leptin levels were 9.57 ng/ml in controls. In mild pre-eclampsia,leptin levels were 25.57 ng/ml and in severe pre-eclampsia, the levels were 36.47 ng/ml. Mean systolic BPwas found to be 140.0/95mmHg in mild and 160.8/111 mmHg in severe pre-eclampsia, while mean blood pressurein controls was 111.7/75.1 mmHg. Serum levels of leptin were found to be significantly correlated with systolic anddiastolic blood pressure with a p-value of <0.001.Conclusion: From this study, it is concluded that strong correlation exists between serum leptin levels and bloodpressure in normal pregnant and in pre eclampsia patients, hence it may contribute to pathogenesis of pre-eclampsia.