Abstract

Objective: To assess the efficacy of cefiderocol in patients with multidrug-resistant enterobacterales.
Material & Methods: A research study was carried out at Clinical Pathology Laboratory, Pak Emirates Military Hospital (PEMH) Rawalpindi, Pakistan (National University of Medical Sciences).  This study was completed in 6 months from June 2021 to November 2021. Data was analyzed by SPSS version 21.
Results: One hundred and fifty-eight (158) samples of blood, pus, body fluids, urine, and lower respiratory tract aspirates were analyzed. Mueller Hinton Agar (MHA) was used for antimicrobial susceptibility testing for all antimicrobials. Colistin agar was used for Polymyxin E testing. Clinical and Laboratory Standards Institute 2021(CLSI) was followed for result interpretation, among 158 MDR enterobacterales, 154 were sensitive to cefiderocol. 
Conclusion: Cefiderocol came out to be the most active among all the tested antimicrobials. It had good efficacy against MDR Enterobacterales.